Skeletal metastasis is an important cause of mortality in patients with breast cancer. Hence, animal mod-els, in combination with various imaging techniques, are in high demand for preclinical assessment of novel therapies. We evaluated the applicability of flat-panel volume computed tomography (fpVCT) to noninvasive detection of osteolytic bone metastases that develop in severe immunodeficient mice after intracardial in-jection of MDA-MB-231 breast cancer cells. A single fpVCT scan at 200-Mm isotropic resolution was em-ployed to detect osteolysis within the entire skele-ton. Osteolytic lesions identified by fpVCT correlated with Faxitron X-ray analysis and were subsequently confirmed by histopathological examination. Isotropic three-dimens...
The growth of primary tumors and metastases is associated with excess body fat. In bone metastasis f...
Following intracardiac delivery of MDA-MB-231-luc-D3H2LN cells to Nu/Nu mice, systemic metastases de...
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appe...
Skeletal metastasis is an important cause of mortality in patients with breast cancer. Hence, animal...
AbstractSkeletal metastasis is an important cause of mortality in patients with breast cancer. Hence...
AbstractNoninvasive methods are strongly needed to detect and quantify not only tumor growth in muri...
Bone is one of the most common metastatic target sites in breast cancer, with more than 200 thousand...
Noninvasive radiologic imaging has recently gained considerable interest in basic, preclinical resea...
AbstractNoninvasive radiologic imaging has recently gained considerable interest in basic, preclinic...
Noninvasive radiologic imaging has recently gained considerable interest in basic and preclinical re...
AbstractCancer drug development generally performs in vivo evaluation of treatment effects that have...
Breast cancer is one of the main cancer-associated causes of death in women. While a primary tumor c...
Flat-panel volume computed tomography (fpVCT) is a recent development in imaging. We discuss some of...
Cancer is a global epidemic; over 1.5 million new cancer diagnoses and greater than 600,000 deaths d...
<div><p>Radiographic imaging plays a crucial role in the diagnosis of osteosarcoma. Currently, compu...
The growth of primary tumors and metastases is associated with excess body fat. In bone metastasis f...
Following intracardiac delivery of MDA-MB-231-luc-D3H2LN cells to Nu/Nu mice, systemic metastases de...
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appe...
Skeletal metastasis is an important cause of mortality in patients with breast cancer. Hence, animal...
AbstractSkeletal metastasis is an important cause of mortality in patients with breast cancer. Hence...
AbstractNoninvasive methods are strongly needed to detect and quantify not only tumor growth in muri...
Bone is one of the most common metastatic target sites in breast cancer, with more than 200 thousand...
Noninvasive radiologic imaging has recently gained considerable interest in basic, preclinical resea...
AbstractNoninvasive radiologic imaging has recently gained considerable interest in basic, preclinic...
Noninvasive radiologic imaging has recently gained considerable interest in basic and preclinical re...
AbstractCancer drug development generally performs in vivo evaluation of treatment effects that have...
Breast cancer is one of the main cancer-associated causes of death in women. While a primary tumor c...
Flat-panel volume computed tomography (fpVCT) is a recent development in imaging. We discuss some of...
Cancer is a global epidemic; over 1.5 million new cancer diagnoses and greater than 600,000 deaths d...
<div><p>Radiographic imaging plays a crucial role in the diagnosis of osteosarcoma. Currently, compu...
The growth of primary tumors and metastases is associated with excess body fat. In bone metastasis f...
Following intracardiac delivery of MDA-MB-231-luc-D3H2LN cells to Nu/Nu mice, systemic metastases de...
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appe...