Pages 201–210 New insights into the genetics of multiple sclerosis

Abstract—Tissue injury in multiple sclerosis (MS) results from an abnormal immune response to one or more myelin antigens that develop in genetically susceptible individuals after exposure to a causal agent that is yet undefined. The genetic component of MS etiology is believed to result from the action of several genes of moderate effect. The incomplete penetrance of MS susceptibility alleles probably reflects inter-actions with other genes, posttranscriptional regulatory mecha-nisms, and significant environmental influences. Equally significant is that genetic heterogeneity also likely exists, meaning that specific genes influence susceptibility and patho-genesis in some affecteds but not in others. Some loci may be involved in the initial pathogenic events, while others could influence the development and progression of the disease. The past few years have seen significant progress in the develop-ments of laboratory and analytical approaches to study non-Mendelian complex genetic disorders and to define the patho-logical basis of demyelination. These developments have set the stage for the final characterization of the genes involved in MS susceptibility and pathogenesis. The identification and characterization of the genes are likely to define the basic etiol-ogy of the disease, improve risk assessment, and influence therapeutics