Effect of Amifostine to prevent Radiotherapy-Induced Acute and Late Toxicity in Head and Neck Cancer Patients Who had Normal or Mild Impaired Salivary Gland Function

Vutisiri Veerasarn Md
Pramook Phromratanapongse Md
Nan Suntornpong Md
Vicharn Lorvidhaya Md
Vimol Sukthomya Md
Imjai Chitapanarux Md
Chanawat Tesavibul Md
Thiti Swangsilpa Md
Cholakiet Khorprasert Md
Kanjana Shotelersuk Md
Yongyut Kongthanarat Md
Apichart Panichevaluk Md
Sunanta Chiewvit Md
Pawana Pusuwan Md
Monreudee Aekmahachai Md
Samart Ratchadara Md
Sasitorn Sirilipoche Md
Yuttana Saengsuda Md

Publication date

December 2014

Abstract

Background: Amifostine has a potential role for salivary gland protection in head and neck cancer patients who had radiotherapy. Material and Method: Sixty-seven head and neck cancer patients were randomized to receive radiotherapy or radiotherapy plus Amifostine. The efficacy of the treatment was determined by a questionnaire evaluating dryness of mouth and the oral comfort, the RTOG/EORTC acute/late radiation morbidity scoring criteria, collection of the whole saliva and the 99mTc-pertecnetate scintigraphy of the salivary glands. Results: Amifostine significantly reduced the mean questionnaire scores from 6.49 to 3.73, the incidence o

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Effect of Amifostine to prevent Radiotherapy-Induced Acute and Late Toxicity in Head and Neck Cancer Patients Who had Normal or Mild Impaired Salivary Gland Function

Abstract

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Effect of Amifostine to prevent Radiotherapy-Induced Acute and Late Toxicity in Head and Neck Cancer Patients Who had Normal or Mild Impaired Salivary Gland Function

Abstract

Extracted data

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