Quantitative SPECT Leads to Improved Performance in Discrimination Tasks Related to Prodromal Alzheimer’s Disease

We investigated the impact of the quantitation and reconstruc-tion protocol on clinical tasks. The performance of standard clinical reconstruction procedures in discrimination tasks re-lated to the diagnosis of prodromal Alzheimer’s disease (AD) was compared with the performance of a quantitative approach incorporating improved corrections for scatter, attenuation, in-trinsic spatial resolution, and distance-dependent spatial reso-lution. Methods: Seventeen normal controls (normal group), 56 subjects who did not have dementia, who did have memory problems, but who did not develop AD within 5 y of follow-up (questionable group), and 27 subjects who did not have demen-tia, who did have memory problems, and who did develop AD over the follow-up period (converter group) were considered in this study. 99mTc-hexamethylpropyleneamine oxime SPECT and MRI studies were performed for each subject at baseline. Th