Functional Mapping of Regional Liver Asialoglycoprotein Receptor Amount from Single

The objective of this study was to validate a method for esti-mating regional liver asialoglycoprotein (ASGP) receptor amount from single blood samples using static SPECT with 99mTc-diethylenetriaminepentaacetic acid galactosyl human se-rum albumin (99mTc-GSA). Methods: Based on a 2-compart-ment nonlinear model, regional ASGP receptor amount could be calculated from total liver ASGP receptor amount (Ro) and regional GSA uptake at a specific time. Because Ro could be estimated from single blood samples using an empiric formula, regional GSA uptake obtained as a SPECT voxel count could be converted to regional ASGP receptor amount by solving a non-linear model equation. To validate this method, data from 62 patients with chronic liver disease underwent dynamic SPECT (30 rotations per 30 min) and simultaneous multiblood sampling and were analyzed by this method. Ro was calculated as th