Atlas of Genetics and Cytogenetics in Oncology and Haematology JAK2 mutations in myeloproliferative neoplasms

Myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells that clinically manifest as overproduction of cells that contribute to the myeloid lineage. These include the "classical MPN's " chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) (Vardiman et al., 2002), as well as "atypical MPN's"; chronic eosinophili