STK15 polymorphism and breast cancer risk in a population-based study

STK15 is considered a potential cancer susceptibility gene owing to its functions in normal cell mitosis. Two common coding region polymorphisms in the gene (F31I and V57I) may affect ubiquitin-dependent degradation and thus the half-life of the encoded protein. There are limited data on the relevance of these polymorphisms to population cancer rates. To examine whether functional variation in STK15 may affect breast cancer risk, we genotyped a large series of incident breast cancer cases (n 941) and age-matched population controls (n 830) for the F31I and V57I poly-morphisms. Individually, neither the F31I polymorphism [odds ratio (OR) 1.54; 95 % confidence interval (CI) 0.96--2.47, comparing 31I with 31F homozygotes] nor the V57I polymorphism (OR 0.92; 95 % CI 0.50--1.71, compar-ing 57I with 57V homozygotes) was significantly associate