COHORT PROFILE Cohort Profile: Risk patterns and processes for psychopathology emerging during

How did the study come about? Mental illness makes a major contribution to the global burden of disease. The impact of disorders such as depression and anxiety has been heightened by the increasing success of public health measures in control-ling physical diseases. Mental health disorders are severely impairing in their own right but may also exacerbate the disability resulting from physical dis-ease. The situation will be worse globally as the pattern of morbidity seen in the developed world sweeps over low- and middle-income countries. Mental illness is commonly understood to result from complex interac-tions between vulnerability and stress, though such a model is uniquely difficult to study, particularly in long-itudinal or life course designs. A considerable propor