Association between Duration of Obesity and Risk of Non-Insulin-Dependent Diabetes Mellitus The Sotetsu Study

The authors investigated the association between duration of obesity (ordinary obesity as body mass index (BMI) (kg/m2)>25.0 and extreme obesity as BMI £27.8) and the risk of diabetes mellitus. Male employees of a railway company, aged 30 years or older, observed for 10 years or more, free from serious disease conditions, with initial BMI <25.0, aged 30 years or more at the time diabetes was diagnosed, and with complete data, were examined by univariate and multivariate analyses (n = 1,598). Age-adjusted odds ratios for diabetes were significantly increased among males who were obese for 10-19.9 years and>20 years (odds ratios = 2.10 and 2.84 for ordinary obesity and 6.14 and 4.15 for extreme obesity, respectively). Additional adjustment for current obesity, physical activity, smoking, drinking, family history, and observation period did not change the findings remarkably. In conclusion, £10 years duration of ordinary obesity or £1 year of extreme obesity was an important predictor for diabetes independent of age, current obesity, physical activity, smoking, drinking, family history, and observation period. Am J Epidemiol 1999;149:256-60. diabetes mellitus, non-insulin-dependent; obesity At present, there is a global epidemic of non-insulin-dependent diabetes mellitus with projected morbidity and mortality that are both of enormou