Quorum-sensing in Pseudomonas aeruginosa and Salmonella: Active natural compounds as antagonists.

The cell to cell communication and regulation systems in bacteria are generally known as quorum sensing. The basic principles of such processes consist of a simplified two-step flow: first, some bacteria emit certain signalling molecules. These are then recognised by the bacteria present in the close neighbourhood, allowing them to develop the production of substances and other functions in the cells, which facilitates a quick transference of the signal to produce or regulate substances in all the cells in a synchronised manner. Specifically, there are some regulation mechanisms by quorum sensing that permit the colonisation and virulence in Salmonella, as well as the colonisation and formation of biofilms in Pseudomonas according to the model of Cystic Fibrosis. Some of these processes are inhibited by diverse substances which would provide new perspectives in the fight against certain illnesses