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ausal women. Moreover, a fairly robust observed only in postmenopausal women (Rose et al. 2004). Adipose tissue is the site of peripheral only a fat-storing tissue but also an endocrine organ Endocrine-Related Cancer (2007) 14 669–677obesity with insulin resistance has also been well-aromatization of adrenal androgens to estrogens (Bulun et al. 1994), and obesity-related elevations in estrogens have been associated with increased breast cancer risk (Yager & Davidson 2006). A strong association of secreting various cytokines, including adiponectin. Adiponectin is a recently identified adipocyte-secreted hormone (Chandran et al. 2003). Adiponectin stimu-lates the sensitivity of peripheral tissues to insulin, and Evidence is accumulating that obesity and insulin resistance are implicated in the etiology of breast cancer that insulin and insulin-like growth factors may play a