This study demonstrates the presence of a novel endothelin (ET) receptor subtype that displays high affinity for both ETA-and ETB-selective ligands. This subtype has been identified in canine spleen membranes using ETB-selective agonists ET-3, IRL-1620, sarafotoxin 6c (S6c) as well as ETA-selective antag-onists BQ123 and related cyclic pentapeptides. Binding of 125I-ET-3 to canine spleen membranes was specific and satu-rable with an apparent dissociation constant of 130 pM and maximum binding (Bmax) of 240.0 fmol/mg protein. Although the apparent affinities obtained with 125I-ET-1 and 125I-ET-3 were comparable (90 and 130 pM, respectively), the maximum binding obtained with 125I-ET-3 was;35 % of that obtained with 125I-ET-1, which indicates...
The molecular basis for recognition of peptide ligands endothelin-1, -2 and -3 in endothelin recepto...
The ability of endothelin (ET) isopeptides to interact with ET receptor subtypes and stimulate phosp...
AbstractAimsTo determine the pharmacology of ETA- and ETB-mediated β-arrestin recruitment and compar...
Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney...
SummaryAll three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expres...
The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 acti...
The data presented in this manuscript describes the binding characteristics of [‘H]SB 209670, a pote...
AbstractIn the inhibition of specific binding or [125]endothelins (ETs) to membranes from various ti...
Receptor binding and antagonist properties of an endothelin (ET) receptor antagonist, TAK-044 {cyclo...
Endothelin-1 (ET-1), a potent vasoactive peptide, was first isolated from cultured porcine endotheli...
BACKGROUND: Endothelin (ET)-1 has potent vascular effects. Two endothelin receptors have been cloned...
All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in ...
Endothelins (ET) are a family of vasoactive peptides that act via two subtypes of receptors, named E...
1 The pharmacological properties of endothelin receptors (ETR) were investigated in guinea-pig bronc...
Endothelin (El) peptides are growth factors that bind to G protein-coupled receptors and serve as a ...
The molecular basis for recognition of peptide ligands endothelin-1, -2 and -3 in endothelin recepto...
The ability of endothelin (ET) isopeptides to interact with ET receptor subtypes and stimulate phosp...
AbstractAimsTo determine the pharmacology of ETA- and ETB-mediated β-arrestin recruitment and compar...
Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney...
SummaryAll three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expres...
The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 acti...
The data presented in this manuscript describes the binding characteristics of [‘H]SB 209670, a pote...
AbstractIn the inhibition of specific binding or [125]endothelins (ETs) to membranes from various ti...
Receptor binding and antagonist properties of an endothelin (ET) receptor antagonist, TAK-044 {cyclo...
Endothelin-1 (ET-1), a potent vasoactive peptide, was first isolated from cultured porcine endotheli...
BACKGROUND: Endothelin (ET)-1 has potent vascular effects. Two endothelin receptors have been cloned...
All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in ...
Endothelins (ET) are a family of vasoactive peptides that act via two subtypes of receptors, named E...
1 The pharmacological properties of endothelin receptors (ETR) were investigated in guinea-pig bronc...
Endothelin (El) peptides are growth factors that bind to G protein-coupled receptors and serve as a ...
The molecular basis for recognition of peptide ligands endothelin-1, -2 and -3 in endothelin recepto...
The ability of endothelin (ET) isopeptides to interact with ET receptor subtypes and stimulate phosp...
AbstractAimsTo determine the pharmacology of ETA- and ETB-mediated β-arrestin recruitment and compar...