2 A Particle Method for Blood Flow Simulation, – Application to Flowing Red Blood Cells and Platelets –

Abstract A new computer simulation using a particle method was proposed to analyze the microscopic behavior of blood flow. A simulation region, including plasma, red blood cells (RBCs) and platelets, was modeled by an assembly of discrete particles. The proposed method was applied to the motions and deforma-tions of a single RBC and multiple RBCs, and the thrombogenesis caused by platelet aggregation. It is expected that, combined with a sophisticated large-scale computational technique, the simulation method will be useful for understanding the overall properties of blood flow from blood cellular level (microscopic) to the resulting rheological properties of blood as a mass (macroscopic)