As a sustained release preparation of diclofenac sodium (DF-Na), we developed a preparation (SR318B) that was expected to exhibit a persistent analgesic effect by once-daily oral administration. In this study, we investigated the persistence of the analgesic effect of SR318B using female cynomolgus monkeys with arthritis induced by sensitization with bovine type II collagen combined with Freund’s complete adjuvant. Cynomolgus monkeys in which arthritis was induced to the same severity received oral administration of SR318B (1 mg DF-Na/kg) once daily for 14 days. The mean ellipsoid area of the proximal interphalangeal joints in the monkeys slightly increased before administration on day 3 in the control group. In contrast, the area decreased...
Because collagen type V (Col V) can be exposed in tissue injury, we hypothesized that oral administr...
Knee osteoarthritis (OA) is a common degenerative disease. Intra-articular administration of flurbip...
Lameness is a common, costly, and painful affliction in cattle at all production levels. There are c...
Intra-articular administration of sustained-release anti-inflammatory drugs is indicated in horses s...
Abstract Background We have reported that a single intra-articular injection of diclofenac etalhyalu...
Background. Since NSAIDS have some detrimental side effects, studying new combinations of NDAIDS wit...
Abstract Background Osteoarthritis (OA) is the most common joint disorder worldwide and one of the l...
Purpose: To prepare and characterize transdermal films of diclofenac diethanolamine as a safer and m...
Topical diclofenac sodium (pennsaid) is a non-steroidal-anti- inflammatory drug that is used to mana...
<p>Animals received subcutaneous injections of saline (Sal) or λ-carrageenan (Carr) into the plantar...
Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2010.Most individuals a...
According to modern ideas, pain is a multidisciplinary problem with serious medical and socio-econom...
Abstract—The study was aimed to investigate the effect of technologically treated diclofenac (releas...
Objectives: Topical forms of Non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain, feve...
A local sustained-release drug delivery system, or depot, for intra-articular injection offers the o...
Because collagen type V (Col V) can be exposed in tissue injury, we hypothesized that oral administr...
Knee osteoarthritis (OA) is a common degenerative disease. Intra-articular administration of flurbip...
Lameness is a common, costly, and painful affliction in cattle at all production levels. There are c...
Intra-articular administration of sustained-release anti-inflammatory drugs is indicated in horses s...
Abstract Background We have reported that a single intra-articular injection of diclofenac etalhyalu...
Background. Since NSAIDS have some detrimental side effects, studying new combinations of NDAIDS wit...
Abstract Background Osteoarthritis (OA) is the most common joint disorder worldwide and one of the l...
Purpose: To prepare and characterize transdermal films of diclofenac diethanolamine as a safer and m...
Topical diclofenac sodium (pennsaid) is a non-steroidal-anti- inflammatory drug that is used to mana...
<p>Animals received subcutaneous injections of saline (Sal) or λ-carrageenan (Carr) into the plantar...
Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2010.Most individuals a...
According to modern ideas, pain is a multidisciplinary problem with serious medical and socio-econom...
Abstract—The study was aimed to investigate the effect of technologically treated diclofenac (releas...
Objectives: Topical forms of Non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain, feve...
A local sustained-release drug delivery system, or depot, for intra-articular injection offers the o...
Because collagen type V (Col V) can be exposed in tissue injury, we hypothesized that oral administr...
Knee osteoarthritis (OA) is a common degenerative disease. Intra-articular administration of flurbip...
Lameness is a common, costly, and painful affliction in cattle at all production levels. There are c...