Add to ORKGAbstractPCancellous bone architecture and mechanics are intimately related. The trabecular architecture of cancellous bone is considered determined by its mechanical environment (Wolffs law). and the mechanical properties of cancellous bone are inversely determined by the trabecular architecture and material properties. Much effort has been spent in expressing these relations, but the techniques and variables necessary for this have not been fully identified. It is obvious, however, that some measure of architectural anisotropy (fabric) is needed. Within the last few years, volume-based measures of fabric have been introduced as alternatives to the mean intercept length method, which has some theoretical problems. This paper seeks to answer...