The known breast cancer susceptibility genes only account for 20 % to 25 % of the excess familial risk of the disease [1]. The present study assessed the contribution of BRCA1/2 mutations and CHEK2 variants to the relative risk of breast cancer for women with affected mothers or sisters. The familial relative risks were estimated by Poisson regression based on the Swedish Family-Cancer Database. The Database was also used to calculate the distribution of life expectancy, the number of daughters per family and the age specific cumulative risk of female breast cancer. This information, together with the penetrances of BRCA1, BRCA2 and CHEK2 from the literature, was used to simulate the familial clustering of breast cancer under different scen...
Family history has long been recognized to be a potent risk factor for breast cancer [1]. Family his...
tibility genes involved in hereditary breast cancer. This study was undertaken to provide reliable p...
Approximately 5–10% of all breast cancer cases are considered to be hereditary. BRCA1 and BRCA2 gene...
Abstract The known breast cancer susceptibility genes only account for 20% to 25% of the excess fami...
In computing the probability that a woman is a BRCA1 or BRCA2 carrier for genetic counselling purpos...
The need to answer the question "how much of the familial risk is currently explained by the known g...
BACKGROUND: BRCA1 and BRCA2 are the two major susceptibility genes involved in hereditary breast can...
Background: Having a family history of breast cancer, par-ticularly if it involves early-onset disea...
Apart from gender, family history is the most important risk factor for breast cancer. In 5-10 % of ...
The need to answer the question “how much of the familial risk is currently explained by the known g...
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation ...
SummaryThe contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mu...
BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives...
For genetic counselling of a woman on familial breast cancer, an accurate evaluation of the probabil...
The purpose of this research was to model the familial clustering of breast cancer and to provide an...
Family history has long been recognized to be a potent risk factor for breast cancer [1]. Family his...
tibility genes involved in hereditary breast cancer. This study was undertaken to provide reliable p...
Approximately 5–10% of all breast cancer cases are considered to be hereditary. BRCA1 and BRCA2 gene...
Abstract The known breast cancer susceptibility genes only account for 20% to 25% of the excess fami...
In computing the probability that a woman is a BRCA1 or BRCA2 carrier for genetic counselling purpos...
The need to answer the question "how much of the familial risk is currently explained by the known g...
BACKGROUND: BRCA1 and BRCA2 are the two major susceptibility genes involved in hereditary breast can...
Background: Having a family history of breast cancer, par-ticularly if it involves early-onset disea...
Apart from gender, family history is the most important risk factor for breast cancer. In 5-10 % of ...
The need to answer the question “how much of the familial risk is currently explained by the known g...
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation ...
SummaryThe contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mu...
BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives...
For genetic counselling of a woman on familial breast cancer, an accurate evaluation of the probabil...
The purpose of this research was to model the familial clustering of breast cancer and to provide an...
Family history has long been recognized to be a potent risk factor for breast cancer [1]. Family his...
tibility genes involved in hereditary breast cancer. This study was undertaken to provide reliable p...
Approximately 5–10% of all breast cancer cases are considered to be hereditary. BRCA1 and BRCA2 gene...