CLINICAL RELEVANCE OF THREE SUBTYPES OF PRIMARY SINONASAL LYMPHOMA CHARACTERIZED BY IMMUNOPHENOTYPIC ANALYSIS

Abstract: Background. The purpose of this study was to investigate the clinical relevance of subtypes categorized by immunophenotypic analysis in primary sinonasal lymphomas. Methods. Eighty patients with localized non-Hodgkin’s lym-phoma involving the nasal cavity and/or paranasal sinuses were divided into three subtypes on the basis of their immunohisto-chemical findings: (A) B-cell lymphoma (n = 19), (B) T-cell lym-phoma (n = 27), and (C) natural killer (NK)/T-cell lymphoma (n = 34). The clinicopathologic profiles, immunophenotypic data, patterns of treatment failure, and survival data among the three patient groups were retrospectively compared. Results. The nasal cavity was the predominant site of involvement in T-cell and NK/T-cell lymphoma, whereas sinus involvement without nasal disease was common in B-cell lymphoma. Systemic B symptoms were frequently observed i