REPORTS The Chondramides: Cytostatic Agents From Myxobacteria Acting on the

depsipeptides produced by strains of the myxobacterium, Chondromyces cro-catus. These peptides, which have been reported to inhibit yeast and mamma-lian cell proliferation, are related to jasplakinolide, which has been isolated from marine sponges of the genus Jas-pis and has been shown to interfere with the actin cytoskeleton (a struc-tural component of cells that helps maintain their shape and is involved in processes, such as cell division and cell locomotion). We studied the effects of the chondramides (A, B, C, and D) on tumor cell growth, on cytoskeleta