The inability to eradicate a population of single, isolated, blood-borne tumor cells with the radionuclides currently in use may limit the efficacy of adjuvant radioimrnunotherapy. We have exam ined the possibility of sterilizing single blood-borne cells using surface-bound emitters of Auger and conversion electrons. Methods: The number of cell-surfacedecays requiredfor 99% sterilization was found by using the linear-quadratic model of cell survival (a = 0.3 Gy"1, alß = 10 Gy) to transform absorbed dose to survival probability. The absorbed dose to the center of the cell was calculated by evaluating the point dose kernel at the cell radius of 6 /¿mand multiplying it by the number of surface decays. A two-compartment model of whole-bo...
Recently, targeted radionuclide therapy (TRT) with radionuclide-derived short-range radiation has be...
Introduction: Because of its favorable half-life (6.02 hours) and distinct characteristic gamma-line...
We here propose a new model assembly for estimating the surviving fraction of cells irradiated with ...
The metastable radionuclide Pt-195m decays predominantly by internal conversion (IC) with a half-lif...
Introduction: The efficiency of 125I in killing tumour cells was compared in vitro and in vivo accor...
Objective Radionuclide therapy with low-energy auger electron emitters may provide high antitumor ef...
Background: Targeted radiotherapy is one of the important methods of radiotherapy that involves the ...
PURPOSE: Radioactive atoms attached to monoclonal antibodies are used in radioimmunotherapy to treat...
Patients with B-cell lymphoma may have disease manifestations ranging in size from more than a 1000 ...
Bone marrow ablation, i.e., the complete sterilization of the active bone marrow, followed by bone m...
International audienceBackground: Targeted radionuclide therapy (TRT) is gaining importance. For TRT...
We here propose a new model assembly for estimating the surviving fraction of cells irradiated with ...
International audienceBackground: In the context of predicting biological effects in Targeted Alpha ...
Introduction: Because of its favorable half-life (6.02 hours) and distinct characteristic gamma-ray ...
International audienceIn the context of predicting biological effects in Targeted Alpha Therapy (TAT...
Recently, targeted radionuclide therapy (TRT) with radionuclide-derived short-range radiation has be...
Introduction: Because of its favorable half-life (6.02 hours) and distinct characteristic gamma-line...
We here propose a new model assembly for estimating the surviving fraction of cells irradiated with ...
The metastable radionuclide Pt-195m decays predominantly by internal conversion (IC) with a half-lif...
Introduction: The efficiency of 125I in killing tumour cells was compared in vitro and in vivo accor...
Objective Radionuclide therapy with low-energy auger electron emitters may provide high antitumor ef...
Background: Targeted radiotherapy is one of the important methods of radiotherapy that involves the ...
PURPOSE: Radioactive atoms attached to monoclonal antibodies are used in radioimmunotherapy to treat...
Patients with B-cell lymphoma may have disease manifestations ranging in size from more than a 1000 ...
Bone marrow ablation, i.e., the complete sterilization of the active bone marrow, followed by bone m...
International audienceBackground: Targeted radionuclide therapy (TRT) is gaining importance. For TRT...
We here propose a new model assembly for estimating the surviving fraction of cells irradiated with ...
International audienceBackground: In the context of predicting biological effects in Targeted Alpha ...
Introduction: Because of its favorable half-life (6.02 hours) and distinct characteristic gamma-ray ...
International audienceIn the context of predicting biological effects in Targeted Alpha Therapy (TAT...
Recently, targeted radionuclide therapy (TRT) with radionuclide-derived short-range radiation has be...
Introduction: Because of its favorable half-life (6.02 hours) and distinct characteristic gamma-line...
We here propose a new model assembly for estimating the surviving fraction of cells irradiated with ...