AN ACTIVE, INTEGRATED BUBBLE TRAP AND DEBUBBLER FOR MICROFLUIDIC APPLICATIONS

We present a novel, fully integrated microfluidic bubble trap and debubbler. The 2-layer structure, based on a PDMS valve design, utilizes a featured membrane to stop bubble progression through the device. A pneumatic chamber directly above the trap is evacuated, and the bubble is pulled out through the gas-permeable PDMS mem-brane. Normal device operation, including continuous flow at atmospheric pressure, is maintained during the entire trapping and debubbling process. We present a range of trap sizes, from 2- to 10-mm diameter, and can trap and remove bubbles up to 25 μL in under 3 hours