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Fire was arguably the most important forest and rangeland disturbance process in the Inland Northwest United States for millennia. Prior to the Lewis and Clark expedition, fire regimes ranged from high-severity with return intervals of 1 to 5 centuries, to low-severity with fire-free periods lasting 3 decades or less. Indoamerican burning contributed to the fire ecology of grasslands and lower and mid-montane dry forests, especially where ponderosa pine was the dominant overstory species, but the extent of this contribution is difficult to quantify. Two centuries of settlement, exploitation, management, and climate variation have transformed the fire regimes, vegetation and fuel patterns, and overall functionality of these forests. We present a narrative that portrays conditions beginning at the first contact of Euro-American settlers with Indoamericans of the region and extending to the present. Due in part to its geographic isolation, the Inland Northwest was among the last regions to be discovered by Euro-Americans. In 200 years the region has undergone fur trapping and trading, sheep, cattle, and horse grazing, timber harvesting, mining, road construction, native grassland conversion to agricultural production, urban and rural area development, fire prevention, and fire suppression. We highlight key changes to forest landscape patterns and processes that occurred under these combined influences, discuss implications of the changes, an