Add to ORKGSystematic testing of chemical combinations in cell-based disease models can yield novel information on how proteins interact in a biological system, and thus can make important contributions to bio-logical models of those diseases. Such combination screens can also preferentially discover synergies with beneficial therapeutic selectivity, especially when used in high-order mixtures of more than two agents. These studies demonstrate the value obtainable from combination che-mical genetics, and reinforce the growing realization that the most useful paradigm for a drug target is no longer a single molecule in a relevant pathway, but instead the set of targets that can cooperate to produce a therapeutic response with reduced side effects
Examination of the pattern of reagent creation and application in the two-hybrid system since 1989 r...
The design of selective drugs and combinatorial drug treatments are two of the main focuses in moder...
Computational approaches have previously been introduced to predict compounds with activity against ...
Efforts to construct therapeutically useful models of biological systems require large and diverse s...
Drug combinations are hoped to improve treatment response to anti-cancer drugs by targeting the canc...
The majority of diseases are associated with alterations in multiple molecular pathways and complex ...
Abstract Drug combination is becoming a popular strategy for combating complex traits, where combina...
Chemical genetics is based on the ability of small molecules to bind reversibly to biological molecu...
Chemical genetics is a research approach that uses small molecules as probes to study protein functi...
Chemical genetics is a research approach that uses small molecules as probes to study protein functi...
Drug combination that consists of distinctive agents is an attractive strategy to combat complex dis...
Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for al...
Improvements in drug design have historically been centered around structure-based optimization of m...
The development of treatments involving combinations of drugs is a promising approach towards combat...
The development of treatments involving combinations of drugs is a promising approach towards combat...
Examination of the pattern of reagent creation and application in the two-hybrid system since 1989 r...
The design of selective drugs and combinatorial drug treatments are two of the main focuses in moder...
Computational approaches have previously been introduced to predict compounds with activity against ...
Efforts to construct therapeutically useful models of biological systems require large and diverse s...
Drug combinations are hoped to improve treatment response to anti-cancer drugs by targeting the canc...
The majority of diseases are associated with alterations in multiple molecular pathways and complex ...
Abstract Drug combination is becoming a popular strategy for combating complex traits, where combina...
Chemical genetics is based on the ability of small molecules to bind reversibly to biological molecu...
Chemical genetics is a research approach that uses small molecules as probes to study protein functi...
Chemical genetics is a research approach that uses small molecules as probes to study protein functi...
Drug combination that consists of distinctive agents is an attractive strategy to combat complex dis...
Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for al...
Improvements in drug design have historically been centered around structure-based optimization of m...
The development of treatments involving combinations of drugs is a promising approach towards combat...
The development of treatments involving combinations of drugs is a promising approach towards combat...
Examination of the pattern of reagent creation and application in the two-hybrid system since 1989 r...
The design of selective drugs and combinatorial drug treatments are two of the main focuses in moder...
Computational approaches have previously been introduced to predict compounds with activity against ...