CISATRACURIUM VS. ROCURONIUM: A PROSPECTIVE, COMPARATIVE, RANDOMIZED STUDY IN ADULT PATIENTS UNDER TOTAL INTRAVENOUS ANAESTHESIA

Aims: To compare the pharmacodynamics of cisatracurium and rocuronium-induced neuromuscular block follow-ing single dose, allowing either spontaneous or neostigmine-accelerated complete recovery. Methods: Following the ethics committee approval and informed consent, 120 patients scheduled for elective surgery under TIVA with tracheal intubation were randomized into 4 groups with different cisatracurium (CIS, 0.10 or 0.15 mg.kg–1) or rocuronium (ROC, 0.60 or 0.90 mg.kg–1) doses administered. For each patient, the onset time for 95 % depression of T 1, clinical duration until 25 % recovery, recovery index (