THE VARIATION OF PTERIDINE LEVELS IN MOUSE TISSUES DURING EXPOSURE TO MAGNETIC FIELDS

We investigated the alteration of pteridine levels in mouse tissues under the exposure to 50Hz circularly and linearly polarized magnetic fields. Neopterin (NP), biopterin (BP), tetrahydrobiopterin (BH4), pterin (AHP) and GTP-CHI activity were measured. Five week-old mice were exposed continuously in the period of 1,3 and 6 weeks. The circularly polarized magnetic fields may affect the immune system and biosynthetic pathway from q-BH2 to BH4 in mouse due to both changes of NP level and BH4/BP ratio. In horizontally polarized fields, almost the same results were obtained. From these results, magnetic field may affect the pteridine levels in mouse which indicate the indirect estimate of the degree of stress emerging during immune response