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mechanism of alternative expression isoforms between subspecies. array, have been used to detect alternative isoforms [23]. To date, on the basis of genome-wide analysis, about 60 % of human species under different environmental and/or development conditions. But insertion and deletion (indel) of subspecies may contribute to the generation of AS isoform diversity during evolution, leading to expanded populations of AS transcripts in Available online at www.sciencedirect.com Genomics 91 (2008) 1 ☆ Sequence data from this article have been deposited with the GenBank Data © 2007 Elsevier Inc. All rights reserved