MECHANISMS OF EFFECTS OF PLATINUM (II) AND (IV) COMPLExES. COMPARISON OF CISPLATIN AND OxALIPLATIN wITH SATRAPLATIN AND LA-12, NEw PT(IV)-BASED DRUGS.

A b s t r a c t Platinum-based complexes are important drugs for the treatment of cancer diseases. Compared to the commonly used Pt(II) compounds cisplatin and oxaliplatin, the recently reported complexes containing Pt(IV) seem to have several advantages; they are safer, can be used orally, have a higher scope of anticancer effect, and do not show cross-resistance to cisplatin. In the first part, cisplatin and oxaliplatin, and satraplatin and LA-12, the Pt(II) and Pt(IV) complexes, respectively, are characterised. Their structures, range of action and side effects are described. In the following part, the mechanisms of their effects are briefly explained, i.e., transport of the active agents to cells, adduct formation, biotransformation pathways, etc. The last part deals with protective mechanisms of the cell, differences in DNA repair mechanisms, and ideas concerning the development of resistance to these drugs. K e y w o r d