A Gene Repression System in Plants via Chromosome Remodeling by Histone Deacetylases

Eukaryotic genes are regulated by a hierarchy of intricate controls that include modifications to chromatin structure. Within the primary chromatin fiber, DNA is packaged into nucleosomes by core histones. Posttranscriptional modification of nucleosomal histones, particularly through acetylation and deacetylation, is an important mechanism in the regulation of eukaryotic gene expression. Acetylation of the histones by acetyltransferases leads to a relaxed association, and thus, enhances accessibilit