Add to ORKGterized b h gain and se manner. at appear in or BRAF because they result to abnormal extracellular signal–related ki-nase (ERK) signaling. Approximately 13 % and 35 % of CRC contain activating point mutations in the BRAF and KRAS genes, respectively [1–4]. Mutant RAS proteins end up losing their initially high GTPase enzymatic activity [5], with mutations in codon 12 by far the most ediated elleni
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes ...
Second RAF paralogue (BRAF) is a proto-oncogene that encodes a serine/threonine kinase that transduc...
BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1-V600E) or as...
Wild-type KRAS acts as a switch during signal transduction; how-ever, somatic mutations that activat...
(L597V)BRAF mutations are acquired somatically in human cancer samples and are frequently coincident...
International audienceThe RAS/RAF/MEK/MAP kinase cascade transduces signals from the cell surface to...
Activating mutations in KRAS and in one of its downstream mediators, BRAF, have been identified in a...
The classical ERK/MAPK signalling pathway regulated proliferation, differentiation and survival. At ...
Background: Genes in the Ras pathway have somatic mutations in at least 60 % of colorectal cancers. ...
Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the R...
BRAF is a component of the RAF/MEK/ERK signalling cascade which controls fundamental cellular activi...
d, ea oncogenic Ras cooperate to induce melanoma in to extracellular signals (Marshall, 1995). Thus,...
Activating somatic and germline mutations of closely related RAS genes (H, K, N) have been found in ...
Constitutive activation of the kinase cascade involving RAS, RAF, MEK and ERK is common to human can...
Activation of the RAS/RAF/extracellular signal-regulated kinase-mitogen-activated protein kinase/ext...
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes ...
Second RAF paralogue (BRAF) is a proto-oncogene that encodes a serine/threonine kinase that transduc...
BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1-V600E) or as...
Wild-type KRAS acts as a switch during signal transduction; how-ever, somatic mutations that activat...
(L597V)BRAF mutations are acquired somatically in human cancer samples and are frequently coincident...
International audienceThe RAS/RAF/MEK/MAP kinase cascade transduces signals from the cell surface to...
Activating mutations in KRAS and in one of its downstream mediators, BRAF, have been identified in a...
The classical ERK/MAPK signalling pathway regulated proliferation, differentiation and survival. At ...
Background: Genes in the Ras pathway have somatic mutations in at least 60 % of colorectal cancers. ...
Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the R...
BRAF is a component of the RAF/MEK/ERK signalling cascade which controls fundamental cellular activi...
d, ea oncogenic Ras cooperate to induce melanoma in to extracellular signals (Marshall, 1995). Thus,...
Activating somatic and germline mutations of closely related RAS genes (H, K, N) have been found in ...
Constitutive activation of the kinase cascade involving RAS, RAF, MEK and ERK is common to human can...
Activation of the RAS/RAF/extracellular signal-regulated kinase-mitogen-activated protein kinase/ext...
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes ...
Second RAF paralogue (BRAF) is a proto-oncogene that encodes a serine/threonine kinase that transduc...
BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1-V600E) or as...