African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain procedures

Objectives: To examine ethnic differences in pain sensitivity and relationship of pain tolerance to blood pressure and neuroen-docrine factors. Methods: Fifty-one African Americans (24 men, 27 women) and 55 people from other ethnic groups (primarily Caucasian; 26 men, 29 women) were tested twice for pain sensitivity to tourniquet ischemia, thermal heat, and cold pressor tests, once following mental stress and once following rest control. Resting and stress-induced blood pressure (BP), plasma norepineph-rine (NE), and cortisol were assessed. Results: In response to all three pain tests, African Americans had lower pain tolerance relative to Caucasian/Others after both rest and stress. Only the non–African American group showed the expected inverse relationship between BP and pain sensitivity. African Americans had lower cortisol concentrations at rest and stress and showed blunted NE and systolic BP responses to stress. Only in Caucasians/Others was the relationship seen between higher stress-induced BP, cortisol, and NE levels and greater pain tolerance. Conclusions: The results suggest that there are alterations in endogenous pain regulatory mechanisms involving BP, cortisol, and NE in African Americans. Such dysregulation may contribute to the greater rate of clinical pain symptoms they experience. It is hypothesized that greater chronic stress in African Americans may be a contributing factor to the alterations in pain regulation. Key words: African Americans, pain sensitivity, blood pressure, norepinephrine, cortisol. ANOVA analysis of variance; BP blood pressure; NE norepinephrine; SBP systolic blood pressure; SIA stress-in-duced analgesia; TSST Trier Social Stress Test; LC locus coeruleus