HLA Association in Seronegative Spondyloarthritis Patients

ABSTRACT Seronegative spondyloarthropathies (SSA) are a group of inflammatory disorder, which clinically involves axial skeleton, sacroiliac and shoulder joints. These patients often complain of low back pain with prominent morning stiffness or nocturnal pain. The association of HLA-B27 allele and its novel subtypes with spondyloarthropathy remains one of the best examples of a disease association with a hereditary marker. The study population comprises of 6180 suspected SSA patients who were referred to the HLA Laboratory of Sir Hurkisandas Nurrotumdas. Hospital