A New Crescent-shaped Spindle For Drug Dissolution Testing - But Why a New Spindle? Dissolution Technologies

Assessment of drug dissolution from solid oraldosage forms such as tablets and capsules isan established practice,and an integral part of pharmaceutical product development and quality evaluation. The rationale for conducting such a test is based on the fact that for a drug to be absorbed from gastrointestinal (GI) tract to systemic circula-tion, it must be released from the product and dissolved in aqueous based GI tract fluid. In general, without dissolution in aqueous based medium, absorption of the drug in the body may not occur, resulting in lack of anticipated therapeutic effects. Thus drug and drug product dissolution characteris-tics may directly be related to efficacy of a pharma-ceutical product. Considering its critical importance and extensive use, the testing aspect for measuring dissolution i