Psychiatric Medications for the Treatment of Pruritus

Objectives: To review the use of psychiatric medications in the treatment of pruritus.Methods: A literature review was conducted using the key words pruritus, psychiatric, and treatment. Results: Three categories of pruritus are described: dermatologic, systemic, and psychogenic. Peripheral and central nervous system mechanisms of pruritus are reviewed. Conventional dermatologic treatments for pruritus are contrasted with some of the common psychopharmacologic treatment modalities that include anxiolytic, antidepressant, and antipsychotic agents. A treatment algorithm is offered to help guide the treatment of patients with pruritus. Conclusions: Psychiatric medications have been used successfully in the treatment of pruritus that is associated with both psychocutaneous and systemic disorders, which are resistant to conventional treatment. Key words: pruritus, psychopharmacology, treatment, psychocutaneous. 5HT hydroxytryptamine; PGE2 prostaglandin E2; SSRI selec-tive serotonin reuptake inhibitor; TCA tricyclic antidepressant