Immunolocalization of Interleukin-1 Receptors in the Sarcolemma and Nuclei of Skeletal Muscle in Patients With Idiopathic Inflammatory Myopathies

Objective. Interleukin-1 (IL-1) acts via its recep-tors to induce gene expression that mediates protein synthesis involved in inflammation. Increased expres-sion of IL-1 and IL-1 in muscle tissue from patients with polymyositis and dermatomyositis has been dem-onstrated. It is not known whether the reciprocal IL-1 receptors are expressed in human muscle tissue. The purpose of this study was to investigate the expression of IL-1 receptors and their ligands in muscle tissue from patients with myositis and from healthy controls. Methods. Muscle biopsy tissues from 10 patients with polymyositis or dermatomyositis and 7 healthy control subjects were investigated by immunohisto-chemistry using antibodies against IL-1 receptor type I (IL-1RI), IL-1RII, IL-1, IL-1, and IL-1 recepto