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For much of their history the relationship between anthropology and psychology is well captured by Robert Frost’s poem, “Mending Wall ” which ends with the ironic line, “good fences make good neighbors. ” The congenial fence was that anthropology studied what people think and psychology studied how people think. Recent research, however, shows that content and process cannot be neatly segregated, because cultural differences in what people think affect how people think. To achieve a deeper understanding of the relation between process and content, research must integrate the methodological insights from both anthropology and psychology. We review previous research and describe new studies in the domain of folk biology which examine the cognitive consequences of different conceptualizations of nature and the place of humans within it. The focus is on cultural differences in framework theories (epistemological orientations) among Native-American (Menominee) and European-American children and adults living in close proximity in rural Wisconsin. Our results show that epistemological orientations affect memory organization, (ecological) reasoning, and the perceived role of humans in nature. This research also demonstrates that cultural differences in framework theories have implications for understanding inter-group conflict over natural resources and are relevant to efforts to improve science learning, especially among Native-American children.