Biochemistry The Role of Mitochondrial Lectin in the Work of Creatine

ABSTRACT. Influence of glucose specific lectin separated from the mitochondrial membranes of bovine brain on creatine kinase activity has been studied. It has been observed that inhibition of enzyme activity starts with the lectin action. The inhibition process starts in the conditions of a certain concentration of the components of enzymatic reaction, which presumably facilitates regulation of the reaction. © 2008 Bull. Georg. Natl. Acad. Sci. Key words: creatine kinase, lectin, mitochondria, enzyme. Cells require energy and its main source is ATP. Maintaining ATP homeostasis is especially important. The ATP received through ordinary mitochondrial me-tabolism usually meets the levels required by the cell. However, during increased consumption the energy re-serves are fully consumed and the cell dies. Main role in maintaining ATP homeostasis is attached to creatine kinase (CK) system that is catalyzed by creatine kinase [1, 2]. Existence of isoforms of creatine kinase is an ex