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Principles:Data on changes of haemostatic pa-rameters at altitudes above 5000 m are very lim-ited. So far it is unknown, whether altered coagu-lation could contribute to the development of acute mountain sickness. Methods: Thirty four healthy mountaineers were randomised to two acclimatisation protocols and undertook an expedition on Muztagh Ata (7549 m) in China.Tests were performed at five al-titudes up to 6865 m. Haemostatic parameters, such as PT, aPTT, D-Dimer, APC-Resistance (APCR), von Willebrand Factor activity (RCo), ADAMTS-13 & C-Natriuretic Peptide (CNP) were assessed together with Lake Louise AMS score