Ideggyogy Sz 2007;60(11–12):489–493. 489 ESETISMERTETÉS ONE-AND-A-HALF SYNDROME – TWO CASES

One-and-a-half syndrome is characterized by combination of the clinical features of unilateral horizontal gaze palsy and internuclear ophthalmoplegia. The common symp-toms are double vision and oscillopsia. The lesion is loca-ted in the paramedian pontine reticular formation, involv-ing the centre of horizontal gaze and medial longitudinal fasciculus. More extensive brainstem damage may result in additional neurological signs. The most frequent underly-ing diseases are vascular insults, multiple sclerosis, and brainstem tumor. We present two cases of one-and-a-half syndrome. Both patients had lacunar infarction in the paramedian pontine tegmentum, revealed by MRI. The first patient had isolated eye movement disorder, while the second had additional nuclear-type facial paresis. In the first case brainstem evoked potentials indicated brainstem damage, in the se-cond patient it was normal. Ocular symptoms improved within some days in both patients