Haematologica vol. 84(11):November 1999 Unusual intracellular and extracellular crystal inclusions in light chain multiple myeloma

Herein we report the light microscopy observa-tion of intracellular and interstitial crystalloiddeposits found in the bone marrow of two patients with light chain multiple myeloma (MM). The first patient was a 65-year old female referred to a nephrology unit because of acute renal failure, severe anemia (Hb 6.3 g/dL), and thrombocytope-nia (Plt 92109/L). Electrophoresis showed a marked reduction of total proteins, hypogamma-globulinemia and a monoclonal component ( light chain) in both serum and urine samples. Severe dif-fuse osteoporosis and multiple vertebral collapses were present. The second patient was a 74-year old female with IgG MM, already treated with melphalan-pred-nisone. She came to our observation because of severe anemia, thrombocytopenia, multiple oste