Add to ORKGKEY WORDS morphine dependence; withdrawal; steroids; mass fragmentography AIM: To investigate the effects of morphine dependence and withdrawal on the concentrations of neurosteroids in rat brain. METHODS: A method of simultaneous quantification of neurosteroids by gas chromatography-mass spectrometry (GC-MS) had been established. RESULTS: The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG), progesterone (PROG), and pregenenolone sulfate (PREGS) in rats killed 6 h after the last treatment. In contrast, there were no significant effects of morphine dependence on the brain concentrations of allopregnanolone (AP), dihydroepiandrosterone (DHEA), and dihydroepiandrosterone sul...
Although p.o. self-administration of morphine is a reliable and convenient means of inducing physica...
Effects of morphine administration were studied on cyclic AMP metabolism in several regions of rat b...
Chronic consumption of morphine induces physical dependency, anxiety, and neurodegeneration. In this...
Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, ...
Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, ...
Background and Objective: There is complex interaction between corticosteroids and opioid system rec...
The aim of this study was to investigate the neuroanatomical regions implicated in the expression of...
To examine whether there are sex differences in morphine dependence and its metabolism. Naloxoneprec...
Morfin is a clinically used analgesic drug but also an abusive drug. It has an impact on a wide rang...
Data was acquired to investigate the effects of morphine withdrawal in rats, both in the brain neuro...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Morphine is one of the most commonly used analgesics for pain, but its clinical use may be accompani...
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related br...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Morphine withdrawal usually results in unsuccessful outcomes. Despite partial benefits from alternat...
Although p.o. self-administration of morphine is a reliable and convenient means of inducing physica...
Effects of morphine administration were studied on cyclic AMP metabolism in several regions of rat b...
Chronic consumption of morphine induces physical dependency, anxiety, and neurodegeneration. In this...
Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, ...
Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, ...
Background and Objective: There is complex interaction between corticosteroids and opioid system rec...
The aim of this study was to investigate the neuroanatomical regions implicated in the expression of...
To examine whether there are sex differences in morphine dependence and its metabolism. Naloxoneprec...
Morfin is a clinically used analgesic drug but also an abusive drug. It has an impact on a wide rang...
Data was acquired to investigate the effects of morphine withdrawal in rats, both in the brain neuro...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Morphine is one of the most commonly used analgesics for pain, but its clinical use may be accompani...
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related br...
Abstinence from chronic morphine results in characteristic withdrawal symptoms in humans and experim...
Morphine withdrawal usually results in unsuccessful outcomes. Despite partial benefits from alternat...
Although p.o. self-administration of morphine is a reliable and convenient means of inducing physica...
Effects of morphine administration were studied on cyclic AMP metabolism in several regions of rat b...
Chronic consumption of morphine induces physical dependency, anxiety, and neurodegeneration. In this...