FINASTERIDE-ASSOCIATED MALE INFERTILITY

Finasteride is a potent and specific inhibitor of the 5α-reductase enzyme in men. Clinical studies have shown that finasteride 1mg/day is effective for promoting hair growth in men with male pattern hair loss. However, there is a concern about the use of finasteride, especially in young fertile patients, because of its action on testosterone metabolism. This paper describes 3 cases of young patients who had very poor seminal quality during finasteride treatment (1 mg/day), and their seminal quality greatly improved after cessation of finasteride treatment. Two of them presented with a left varicocele and the other was obese. We hypothesize that finasteride may not dramatically change the spermatogenesis process in healthy men, but in patients with conditions related to infertility, an amplification of the negative influence of finasteride could occur. Future studies should be done to clarify the extent of the effect of finasteride in patients fertility problems. KEY WORDS: Finasteride. Fertility. Spermatogenesis. Sperm. Seminal parameters. Finasteride is a potent and specific inhibitor of the 5α-reductase enzyme.1 It inhibits the conversion of testoster-one to dihydrotestosterone (DHT).2 Dihydrotestosterone is the most potent androgen, and its level directly affect