MECHANISMS OF PARATHYROID HYPERPLASIA IN RENAL FAILURE: ROLE OF PHOSPHATE

In chronic kidney disease (CKD) patients, secondary hyperparathyroidism (SHPT) is characterized by parathyroid (PT) hyperplasia and enhanced synthesis and secretion of PT hormone (PTH). Elevated PTH levels cause renal osteodystrophy and cardiovascular complications, with significant increased morbidity and mortality in renal failure. The three main direct causes of SHP