Maternal periconceptional use of vitamin supplements containing folic acid substantially reduces the risk of neural tube defects (NTDs) in the offspring. The mechanism underlying this reduction in risk is unknown. Several recent studies have reported an association between homozygosity for a variant form (the C677T genotype) of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and risk for NTDs in individuals. It has been hypothesized that maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. Using data from two California case-control interview studies (1987-1991 birth cohorts), the authors investigated whether an interaction for spina bifida...
It is proven that folic acid supplied in the periconceptional period can lower the recurrence and oc...
0Background/aim: Neural tube defects (NTDs) are common congenital malformations that develop as a re...
AbstractBackgroundNeural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in the...
Women who take folic acid periconceptionally reduce their risk of having a child with a neural tube ...
Contains fulltext : 50620.pdf (publisher's version ) (Closed access)AIMS: Periconc...
Contains fulltext : 50079.pdf (publisher's version ) (Open Access)Neural-tube defe...
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism an...
There is a considerable body of data demonstrating that periconceptional supplementation of folic ac...
Abstract Background Neural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in t...
AIMS: Periconceptional folate supplementation prevents neural tube defects and possibly congenital h...
Contains fulltext : 51023.pdf (publisher's version ) (Closed access)The methionine...
Methylenetetrahydrofolate reductase (MTHFR) C677T and catechol-O-Methyltransferase (COMT) G158A are ...
Background: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism an...
Background/aim: Neural tube defects (NTDs) are common congenital malformations that develop as a res...
We welcome the article by Shaw et al. (1), which explored for the first time how maternal periconcep...
It is proven that folic acid supplied in the periconceptional period can lower the recurrence and oc...
0Background/aim: Neural tube defects (NTDs) are common congenital malformations that develop as a re...
AbstractBackgroundNeural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in the...
Women who take folic acid periconceptionally reduce their risk of having a child with a neural tube ...
Contains fulltext : 50620.pdf (publisher's version ) (Closed access)AIMS: Periconc...
Contains fulltext : 50079.pdf (publisher's version ) (Open Access)Neural-tube defe...
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism an...
There is a considerable body of data demonstrating that periconceptional supplementation of folic ac...
Abstract Background Neural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in t...
AIMS: Periconceptional folate supplementation prevents neural tube defects and possibly congenital h...
Contains fulltext : 51023.pdf (publisher's version ) (Closed access)The methionine...
Methylenetetrahydrofolate reductase (MTHFR) C677T and catechol-O-Methyltransferase (COMT) G158A are ...
Background: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism an...
Background/aim: Neural tube defects (NTDs) are common congenital malformations that develop as a res...
We welcome the article by Shaw et al. (1), which explored for the first time how maternal periconcep...
It is proven that folic acid supplied in the periconceptional period can lower the recurrence and oc...
0Background/aim: Neural tube defects (NTDs) are common congenital malformations that develop as a re...
AbstractBackgroundNeural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in the...