Case Report Metastatic Adrenocortical Carcinoma Treated with Sunitinib:

Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Palliative che-motherapy can be considered in patients with metastatic disease. Although mitotane- or cisplatin-based chemotherapy regimens are widely used, the effects of these agents have been limited. We have experienced a case that showed a partial response with sunitinib after failure of mitotane-based cytotoxic chemotherapy. The clinical benefit from sunitinib persisted 7.5 months in this case. To our knowledge, this is the first reported case showing the effects of sunitinib on metastatic ACC. Key words: adrenocortical carcinoma – chemotherapy – sunitini