© C. van der Poel 2008 Influence of temperature-induced reactive oxygen species production on excitation-contraction coupling in mammalian skeletal muscle

1. Here we review evidence obtained recently by us indicating that the poor longevity of isolated mammalian skeletal muscle preparations at temperatures in the normal physiological range is related to the increased production of reactive oxygen species (ROS) in the resting muscle. 2. Temperature-induced ROS production increases markedly above 32°C in isolated, resting skeletal muscle and is associated with the gradual and irreversible functional deterioration of the muscle. 3. The majority of the temperature-induced muscle ROS originate in the mitochondria and act on various sites involved in excitation-contraction coupling