Depression, mood state, and back pain during microgravity simulated by bed rest

Objective: The objective of this study was to develop a ground-based model for spinal adaption to microgravity and to study the effects of spinal adaptation on depression, mood state, and pain intensity. Methods: We investigated back pain, mood state, and depression in six subjects, all of whom were exposed to microgravity, simulated by two forms of bed rest, for 3 days. One form consisted of bed rest with 6 degrees of head-down tilt and balanced traction, and the other consisted of horizontal bed rest. Subjects had a 2-week period of recovery between the studies. The effects of bed rest on pain intensity in the lower back, depression, and mood state were investigated. Results: Subjects experienced significantly more intense lower back pain, lower hemisphere abdominal pain, headache, and leg pain during head-down tilt bed rest. They had higher scores on the Beck Depression Inventory (ie, were more depressed) and significantly lower scores on the activity scale of the Bond-Lader questionnaire. Conclusions: Bed rest with 6 degrees of head-down tilt may be a better experimental model than horizontal bed rest for inducing the pain and psychosomatic reactions experienced in microgravity. Head-down tilt with balanced traction may be a useful method to induce low back pain, mood changes, and altered self-rated activity level in bed rest studies. Key words: depression, mood, lower back pain, lower abdominal pain, leg pain, bed rest. HBR horizontal bed rest; HDT head-down tilt; NASA National Aeronautics and Space Administra-tion