Add to ORKGParagangliomas derive from sympathetic chromaffin tissue in adrenal and extra-adrenal abdominal or thoracic locations, or from parasympathetic tissue of the head and neck. Mutations of nuclear genes encoding subunits B, C and D of the mitochondrial enzyme succinate dehydrogenase (SDHB 1p35-p36.1, SDHC 1q21, SDHD 11q23) give rise to hereditary paraganglioma syndromes PGL4, PGL3 and PGL1, respectively. The susceptibility gene for PGL2 on 11q13.1 remains unidentified. Mitochondrial dysfunction due to SDHx mutations have been linked to tumorigenesis by upregulation of hypoxic and angiogenesis pathways, apoptosis-resistance and developmental culling of neurona
The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; mitochond...
Background: Mutations in the genes encoding B, C, and D subunits of the succinate dehydrogenase (SDH...
Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-producing tumors of the adrenal ...
Pheochromocytomas and paragangliomas are chromaffin cell tumors arising from neuroendocrine cells. A...
Contains fulltext : 79552timmers.pdf (publisher's version ) (Closed access)Paragan...
OBJECTIVE: Hereditary paraganglioma (PGL) syndromes result from germline mutations in genes encoding...
BACKGROUND: Paragangliomas of the head and neck are highly vascular and usually clinically benign tu...
To explore the genotype-phenotype correlation among the different forms of hereditary paraganglioma....
Paragangliomas are rare tumors of neural crest origin. They are benign in the majority of cases and ...
Paragangliomas are tumors arising from sympathetic and parasympathetic tissues. The classic associat...
Extra-adrenal pheochromocytomas, otherwise known as paragangliomas (PGLs), account for about 20% of ...
The four SDH genes encode succinate dehydrogenase (SDHA and SDHB) and its anchoring subunits (SDHC a...
Background: Mutations in the genes encoding B, C and D subunits of the succinate dehydrogenase (SDH)...
Paragangliomas and pheochromocytomas are rare neuroendocrine tumours with a very strong genetic comp...
The pheochromocytomas are an important cause of secondary hypertension. Although pheochromocytoma su...
The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; mitochond...
Background: Mutations in the genes encoding B, C, and D subunits of the succinate dehydrogenase (SDH...
Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-producing tumors of the adrenal ...
Pheochromocytomas and paragangliomas are chromaffin cell tumors arising from neuroendocrine cells. A...
Contains fulltext : 79552timmers.pdf (publisher's version ) (Closed access)Paragan...
OBJECTIVE: Hereditary paraganglioma (PGL) syndromes result from germline mutations in genes encoding...
BACKGROUND: Paragangliomas of the head and neck are highly vascular and usually clinically benign tu...
To explore the genotype-phenotype correlation among the different forms of hereditary paraganglioma....
Paragangliomas are rare tumors of neural crest origin. They are benign in the majority of cases and ...
Paragangliomas are tumors arising from sympathetic and parasympathetic tissues. The classic associat...
Extra-adrenal pheochromocytomas, otherwise known as paragangliomas (PGLs), account for about 20% of ...
The four SDH genes encode succinate dehydrogenase (SDHA and SDHB) and its anchoring subunits (SDHC a...
Background: Mutations in the genes encoding B, C and D subunits of the succinate dehydrogenase (SDH)...
Paragangliomas and pheochromocytomas are rare neuroendocrine tumours with a very strong genetic comp...
The pheochromocytomas are an important cause of secondary hypertension. Although pheochromocytoma su...
The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; mitochond...
Background: Mutations in the genes encoding B, C, and D subunits of the succinate dehydrogenase (SDH...
Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-producing tumors of the adrenal ...