An Evaluation of Lesion Detectability with Cone-Beam, Fanbeam and Parallel-Beam Collimation in SPECT by Continuous ROC Study

ingle-photonemission computed tomography(SPECT) using cone-beam (CB) collimation increases the numberof detected photons compared with conventional acquisition geometries (1—3).However, the advantage of CB collima tion over conventional collimation in terms of lesion de tectability has yet to be evaluated. The evaluation of lesion detectability is a prerequisite for clinical application of CB SPEC!'. In this paper, we compare lesion detectability using CB, fanbeam (FB) and parallel-beam(PB) collima tion using the Hoffman three-dimensionalbrain phantom and continuous receiver operating characteristic (CROC) analysis. Many factors, such as resolution and sensitivity of the detection system, reconstruction algorithm, lesion size and lesion location, affect the lesion detectability. In this study