The Retinoblastoma (Rb) gene was the first tumor suppressor discovered. In many, if not all, human tumors Rb is functionally inactivated. In a normal cell, the Rb protein is a transcription regulator that controls the cell cycle, differentiation, and cell death. Studies have shown that mice carrying one Rb mutant allele (Rb+/-) are highly cancer prone and do not live as long as wild type mice. Furthermore, completely Rb deficient embryos (Rb-/-) die in mid-gestation around the 14th embryonic day (E14) of development. Analysis of Rb-/- embryos reveals defects in hematopoiesis, neurogenesis, and lens fiber development. At least in part, these defects arise from the inappropriate regulation of the cell cycle. Studies of Rb function have led to...
The retinoblastoma susceptibility gene Rb is an important tumour suppressor. It wil l inhibit both g...
The retinoblastoma protein (pRB) plays a key role in the control of normal development and prolifera...
The retinoblastoma (Rb) family of proteins are key regulators of cell cycle exit during development ...
2nd place biological sciences at 2006 Denman Undegrad ForumThe Retinoblastoma (Rb) gene was the firs...
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions ...
Functional inactivation of the retinoblastoma tumor suppressor gene product (RB) is a common event i...
The retinoblastoma family genes, RB, RB2/p130 and p107, play a key role in several aspects of cell b...
The E2f3 locus encodes two Rb-binding gene products, E2F3a and E2F3b, which are differentially regul...
The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcr...
The product of the retinoblastoma tumor suppressor gene (Rb) can control cell proliferation and prom...
Retinoblastoma is a type of cancer that occurs early in child development. This disease is rare, wit...
Abstract Background The RB1 gene was the first tumor suppressor gene cloned from humans by studying ...
AbstractThe retinoblastoma (RB) tumor suppressor gene occupies central roles in cell cycle control a...
Mutation of the retinoblastoma tumour-suppressor gene (RB) leads to the deregulation of many protein...
The retinoblastoma tumor suppressor, RB, is thought to inhibit cell cycle progression through transc...
The retinoblastoma susceptibility gene Rb is an important tumour suppressor. It wil l inhibit both g...
The retinoblastoma protein (pRB) plays a key role in the control of normal development and prolifera...
The retinoblastoma (Rb) family of proteins are key regulators of cell cycle exit during development ...
2nd place biological sciences at 2006 Denman Undegrad ForumThe Retinoblastoma (Rb) gene was the firs...
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions ...
Functional inactivation of the retinoblastoma tumor suppressor gene product (RB) is a common event i...
The retinoblastoma family genes, RB, RB2/p130 and p107, play a key role in several aspects of cell b...
The E2f3 locus encodes two Rb-binding gene products, E2F3a and E2F3b, which are differentially regul...
The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcr...
The product of the retinoblastoma tumor suppressor gene (Rb) can control cell proliferation and prom...
Retinoblastoma is a type of cancer that occurs early in child development. This disease is rare, wit...
Abstract Background The RB1 gene was the first tumor suppressor gene cloned from humans by studying ...
AbstractThe retinoblastoma (RB) tumor suppressor gene occupies central roles in cell cycle control a...
Mutation of the retinoblastoma tumour-suppressor gene (RB) leads to the deregulation of many protein...
The retinoblastoma tumor suppressor, RB, is thought to inhibit cell cycle progression through transc...
The retinoblastoma susceptibility gene Rb is an important tumour suppressor. It wil l inhibit both g...
The retinoblastoma protein (pRB) plays a key role in the control of normal development and prolifera...
The retinoblastoma (Rb) family of proteins are key regulators of cell cycle exit during development ...