Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function after a Lifestyle Modification Trial Among Obese Children

and proinflammatory states with vascular function af-ter diet and exercise intervention among obese chil-dren has not been previously explored. METHODS: In this 6-week diet and exercise interven-tion study in 35 obese children, age 12 to 18 years, we evaluated the relationship between changes in an-thropometric indices, measures of insulin resistance, C-reactive protein (CRP), oxidized LDL (ox-LDL), and oxidative stress markers with changes in carotid intima-media thickness (C-IMT) and flow mediated dilation (FMD) of the brachial artery. RESULTS: At the end of the study, body mass index (BMI), waist circumference, and percentage body fat were decreased (P 0.05), but participants remained overweight (BMI 95th percentile). Although FM