Printed In U.SA. Cohort Mortality Study of Pulp and Paper Mill Workers in British Columbia,

The authors studied a cohort of 30,157 male pulp and paper workers in British Columbia, Canada. Of these, 20,373 worked in kraft mills only, 5,249 in sulftte mills only, and 4,535 in both kraft and sulfrte mills. All workers with at least 1 year of employment on January 1, 1950, or thereafter until December 31, 1992, were studied. Standardized mortality ratios (SMRs) were used to compare the mortality rates of the cohort with those of the Canadian male population. Ninety percent confidence intervals (CIs) for the SMRs were obtained. Cancer risks significantly associated with work duration and time from first employment of 15 years or more were observed: 1) total cohort: pleura (SMR = 3.61, 90 % Cl 1.42-7.58); kidney (SMR = 1.69,90 % Cl 1.13-2.43); brain (SMR = 1.51, 90 % Cl 1.03-2.16); 2) workers in kraft mills only: kidney (SMR = 1.92, 90 % Cl 1.04-3.26); 3) workers in sulfite mills only: Hodgkin's disease (SMR = 4.79, 90 % Cl 1.29-12.37); 4) workers ever employed in both kraft and sulfrte mills: esophagus (SMR = 1.91, 90 % Cl 1.00-3.33). These malignancies have been associated with the following known or suspected carcinogens to which pulp and paper workers may have been exposed: asbestos (pleura), biocides (kidney), formaldehyde (kidney, brain, Hodgkin's disease), hypochlorite (esopha-gus). A nested case-control study with detailed exposure assessment is under way to help determine whether excess risks for specific cancers reflect exposure among subsets of workers. Am J Epidemiol 1997;146: 186-94